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Characteristics of cannabis administration routes - update
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Characteristics of cannabis administration routes - update

 

The effect of cannabis variety is determined by the percentage of cannabinoids, terpenes, flavonoids, and other active substances that we find in the different types, whether they are Sativa, Indian or hybrid. The different profiles of cannabinoids and terpenes will determine the plant's potential for its effects. Terpenes modulate and complement the effects of cannabinoids, dank vapes fruity pebbles provide us with the flavor and each variety and are responsible for the plant's resistance to its predators. 

 

Cannabinoids are chemical, so, predictably, terpenes themselves act in the same way as cannabinoids, through receptors of the endocannabinoid system, in some cases. I believe that cannabinoids are the terpenes that only the cannabis plant synthesizes, Purple kush, and we do not find them in the other varieties of the plant kingdom. The cannabis plant is unique in this regard and its complex composition with about 400 active molecules in each array. I think that cannabinoids only constitute between 20 and 40% of the plant's components.

 

With the legalization of the therapeutic use of cannabis in different states of the USA, the cannabis industry has been generated that has allowed quality cannabis formulations to be administered through various routes. The possibility of helping cannabinoids with controlled doses by inhaled, oral, sublingual, rectal, intranasal, transdermal routes makes it easier for us, from a medical point of view, to use the different paths depending on the pathology. We are going to treat the characteristics of each patient. We already use many of these administration routes, but we have to understand that any administration route can use not all formulations. It must be specifically formulated for this use, and its preparation and components must be specific for this route. We do not have any products currently within reach that can be injected. No cannabis oil can be injected !!!

 

We will therefore review the characteristics of each route of administration.

Terpenes and cannabis are volatile or semi-volatile substances, so their quantification is done by chromatography. It is a technique that serves to characterize compounds from a simple mixture. High precision liquid column chromatography or CBD is the most accurate technique for quantifying cannabis components.Buy 5-Methylethylone Online cheack our new site. 

The chromatography result indicates the quantity of each cannabinoid or terpene analyzed expressed as a percentage concerning 100% of the sample's total weight. If we had a hypothetical variety or product with 10% THC, we directly know that in 100mg of example, there is 10mg of THC. In 1 gr, we would have 100 mgr and so on.

 

In oil dilutions, we find that the weight of 1 ml of virgin olive oil at 24º is 0.928 gr, but it usually works with 1 ml = 1 gr.

 

The different cannabinoids have different effects, like the terpenes, knowing the number of cannabinoids and terpenes of the varieties to use. We could use the different combinations depending on the disease or symptom that the patient presents. It would always be approximate, but various profiles of cannabinoids and terpenes could be prescribed for the different pathologies to be treated.

 

In a way, it allows us to individualize the treatment; also, the final effect of cannabis always depends on multiple factors. 

, we have to use standardized and correctly analyzed products to know the percentage of cannabinoids and terpenes. Besides, control contaminants' possible presence such as heavy metals, pesticides, fungicides, bacteria, fungi, etc.

 

If the herbal material is analyzed correctly,Sleep Gummies,it can be used and dosed accurately for inhalation by vaporization or dissolved and administered orally, for example.

 

The standardized and correctly analyzed products allow us to precisely dose and work with tranquillity and patient safety.

 

We find the disadvantage of the economic cost in some cases, which is determined by the high doses that are must use.

 

We can currently find various formulations on the market, and we can have CBD products that meet the legal requirements to be marketed.

 

Therefore, we can administer cannabinoids through different routes, and there are other formats available in CBD products, duly tested.

 

Cannabinoids can be administered by different routes, although the most common is the inhalation of cannabis, which is combustion by smoking a "joint" that may or may not be mixed with tobacco.

 

From a therapeutic point of view, this route is not recommended in any case. When inhaling the smoke from the joint mixed with tobacco, among other substances we inhale:

 

Hydrogen cyanide, tar, nicotine, carbon dioxide, nitrosamines from tobacco, aromatic amines, ammonia, benzopyrenes. And traces of lead, chromium,Gummies,and nickel, among other substances. Some are carcinogenic, and others toxic at specific doses.

 

Therefore, it is clear that we do not advise in any case the use of cannabis, and we also advise against it when used for recreational purposes.

 

We must bear in mind that the combustion of cannabis without mixing it with tobacco also generates carcinogenic and toxic substances, although we minimize the risks. During the explosion, cannabinoids and terpenes are also lost, retained in the filters, depending on their composition. You can get to waste 50 to 70% of the total cannabinoids when consuming them in this way. Also, keep in mind that paper,milk chocolate,according to its composition, generates harmful substances after combustion, which we also inhale when smoking.

 

Therefore, from a therapeutic point of view, we never recommend this route. Although the final decision is always the patient's, who once informed and advised, decides on the treatment to follow. I think the choice is a patient's right.

 

Then must use the routes of administration of a drug following specific criteria. A painless administration must be tried, that the absorption is regular and that we obtain the highest bioavailability of the product, in this case, the cannabinoids. The bioavailability of a drug would be more or less the relationship between the dose of the administered substance and the level that we obtain in blood after a particular time, which can also quantify.

 

Oral - sublingual route

We can administer cannabinoids generally dissolved in a vegetable oil of olive or sunflower or someone in ethanol for sublingual administration through the oral cavity mucosa. Ethanol is a suitable solvent for cannabinoids, although its taste is a problem for some patients and generates an oropharyngeal burning sensation. The intraoral and sublingual mucosa allows rapid absorption, although some people discuss this route.

 

The oral route presents some problems and also advantages. Bioavailability, in this case, is highly variable and indicates that, by giving the same doses to different patients, we will not find the same blood levels. Good availability would determine similar blood levels in patients given the same amount. With a slight variation in absorption, dosing would be easier. It can take us about two weeks to stabilize a treatment about the doses. That is why it is essential to start with low doses, especially when using THC, until you find the minimum effective quantity, primarily if you use the oral route.Buy 5-Methoxymethylone Powder Online

 

Another problem is that the effect can take between half an hour and up to two hours after the shot. Variability depends on each individual and also on the time of days and activity. Also, the effect is more powerful and lasting than when inhaled—always taking into account the precise doses. How much more powerful? It depends on each individual and the amounts. Be careful when consuming cannabis orally. The cases that end up in the hospital are usually almost all due to oral ingestion.

 

The effect can be from 6 to 10 hours in some cases, although it is a complex objective evaluation subject since many individual factors influence it. The duration of the effects is prolonged can be a disadvantage depending on the activity that the patient has to carry out since some cannabinoids are psychoactive and can limit abilities and control for specific tasks in everyday life.

 

Dilutions are a perfect vehicle for oral administration since we can dose precisely and for the patient, it only represents ingesting a few drops of olive oil or ethanol. Olive oil is an excellent solvent for dilutions. Above all, about preserving terpenes and cannabinoids.

 

We can also find other encapsulated formulations or suppositories for rectal administration.

 

Inhaled via vaporizer

In the case of cannabis, the route with the best bioavailability is undoubtedly inhaled by the respiratory way, and the effect is obtained quickly after inhalation. If a competent vaporizer is used, the path is clean, there is no combustion,

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The inhaled route by vaporization is the one that personally seems to be the most appropriate. However, it carries the problem for many patients to handle herbal products, concentrate, and get quality and analyzed cannabis. We currently have competent vaporizers on the market, which guarantee us precision in the vaporization temperature. This is important because the more temperature range we can select, the better we will take advantage of the plant, and we will be able to choose in a certain way the cannabinoids to inhale.

 

Suppose we vaporize plant sieving, crumbled flowers. In that case, we must consider that the humidity of the grass must be between 65% to 75%. With this humidity, we favour vaporization and minimize the risk of combustion, prolonging the duration of the vaporization session.

 

Above 157º-165º THC is vaporized, and CBD over 178º to 190º, CBN at 185º, THCV at 222º, look the wide temperature range of 150º to 222º. Therefore, if we inhale at 157º a THC / CBD variety with a 1/1 ratio, theoretically, we can administer or consume THC at 157º first and then go up to 190º and vaporize CBD. But this process is not 100% exact either. Suppose we want to get the most out of the plant to inhale the most significant number and quantity of cannabis, terpenes, flavonoids, etc. We must work at a maximum of 200º, and checking that there is no combustion and it produces the usual smoke. The terpenes in general of the cannabis plant vaporize from 156º to 219º; we could use this figure as the maximum.

 

Since there are vaporizers prepared to use extracts, in this case, we will work at temperatures of 200 to 230º range given the density of the product to be vaporized.

 

Transdermal or percutaneous route

Another route that may be useful for some patients or cannabis users is transdermal administration of the skin. Since cannabis dissolves well in fats due to its lipophilic characteristics, it should theoretically have less transdermal penetration than hydrophilic substances. Still, cannabinoid preparations are very effective in most cases applied topically. We can use them both in chronic pathologies, osteoarthritis,milk chocolate , fibromyalgia, rheumatic diseases. The CBD-rich preparations also have an anti-inflammatory and antiproliferative effect, making them effective in psoriasis and hyperkeratotic dermatitis or dry eczema.

 

If we associate Limnane cannabinoids, we improve transdermal absorption since this terpene has the function of facilitating the diffusion through the skin of other compounds, among other actions. Valuable blood levels are not detected after topical application of cannabinoids that may cause a patient's psychoactive effect. Besides, the formulations to apply topically are usually basically rich in CBD, but it also contains THC. The effect, in general, is more powerful, primarily the pain reliever. Expectations for the use of topical products are limited to local processes. Their effect can be an exciting complement to the treatment prescribed by another route at the same time.

 

Rectally

Rectal absorption depends on various factors such as the amount of faecal content or the state of the rectal mucosa, among others. But rectal absorption means that the drug skips the liver passage and goes directly into the general circulation. That must make absorption through the middle and lower hemorrhoidal veins reflect the hepatic step, which in THC.

 

It would be the first metabolic step by hydroxylation 10-hydroxy-THC. Which could be a psychoactive potency up to 4 times higher than THC,blue raspberry,so this route would theoretically represent an alternative way to administer THC in high doses, minimizing the psychoactive effect. But we should think about the correct formulations of THC to help by this route; lipophilic substances are absorbed rectally but slowly.

 

THC must likely be formulated in the form of a hemisuccinate for its correct absorption. Also, the conclusion that the psychoactive effect of THC disappears when we administer it rectally and skip the first hepatic step could be wrong. If we cannot confirm the impact by objective tests, could we think there is no psychoactive effect because it is not absorbed?

 

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